GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UVM | cis | rs1411478 | 1 | rs3789364 | chr1:180951043 | STX6 | chr1:180913175-180992046:- | -0.58 | -5.74 | 4.28E-7 | Progressive supranuclear palsy |
| UVM | cis | rs11190604 | 1 | rs3793706 | chr10:102269085 | SEC31B | chr10:102246403-102289636:- | 0.39 | 5.1 | 4.38E-6 | Palmitoleic acid (16:1n-7) plasma levels |
| UVM | cis | rs11190604 | 1 | rs3793771 | chr10:102222957 | SEC31B | chr10:102246403-102289636:- | -0.39 | -5.11 | 4.24E-6 | Palmitoleic acid (16:1n-7) plasma levels |
| UVM | cis | rs11190604 | 1 | rs3793772 | chr10:102222825 | SEC31B | chr10:102246403-102289636:- | -0.39 | -5.11 | 4.24E-6 | Palmitoleic acid (16:1n-7) plasma levels |
| UVM | cis | rs703842 | 1 | rs3825079 | chr12:58203354 | TSFM | chr12:58176536-58191367:+ | -0.57 | -5.04 | 5.32E-6 | Multiple sclerosis |
| UVM | cis | rs8078723 | 1 | rs3826331 | chr17:38150492 | GSDMA | chr17:38119226-38134019:+ | 0.86 | 7.26 | 1.4E-9 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| UVM | cis | rs12971120 | 1 | rs3829640 | chr18:72174980 | CNDP2 | chr18:72163597-72188356:+ | 0.72 | 5.41 | 1.41E-6 | Refractive error |
| UVM | cis | rs10935120 | 1 | rs3846055 | chr3:134203973 | ANAPC13 | chr3:134196547-134204865:- | 0.46 | 7.11 | 2.47E-9 | Height |
| UVM | cis | rs10935120 | 1 | rs3846056 | chr3:134227292 | ANAPC13 | chr3:134196547-134204865:- | 0.46 | 7.06 | 3.0E-9 | Height |
| UVM | cis | rs10935120 | 1 | rs3932818 | chr3:134206069 | ANAPC13 | chr3:134196547-134204865:- | 0.46 | 7.11 | 2.47E-9 | Height |
| UVM | cis | rs2028299 | 1 | rs3960018 | chr15:90383307 | AP3S2 | chr15:90373832-90456222:- | -0.74 | -6.17 | 8.4E-8 | Type 2 diabetes |
| UVM | cis | rs3981351 | 1 | rs3981351 | chr10:115515120 | CASP7 | chr10:115438935-115490662:+ | 0.46 | 5.12 | 4.09E-6 | Obesity-related traits |
| UVM | cis | rs9902453 | 1 | rs4074170 | chr17:28381141 | EFCAB5 | chr17:28256874-28435469:+ | -0.4 | -5.08 | 4.7E-6 | Coffee consumption (cups per day) |
| UVM | cis | rs4074493 | 1 | rs4074493 | chr1:231172281 | FAM89A | chr1:231154704-231175995:- | 0.54 | 4.75 | 1.49E-5 | Carotid plaque burden (smoking interaction) |
| UVM | cis | rs9902453 | 1 | rs4075623 | chr17:28386526 | EFCAB5 | chr17:28256874-28435469:+ | -0.4 | -5.08 | 4.7E-6 | Coffee consumption (cups per day) |